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CNADK-I90F has a lower K m and higher V max for NAD + compared to wild-type cNADK, which indicates increased enzyme activity

This also results in the opening of the mPTP leading to uncontrolled ROS production and disrupted synaptic maturation causing autistic behaviors [127]

Mechanistically, its claimed effects track the biology of that TB4 motif: regulating actin dynamics, driving cell migration, and supporting new vessel growth and tissue repair

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Based on the computational results, the five predicted non-toxic molecules were selected for the in vitro assay

doi:10.1073/pnas.0813409106, PMID: 19223582 Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK, Gorin F, Bharath MM (2007) Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinsons disease: a dynamic model